To deliver rigorous STEM instruction in which students develop the ability to solve real-world problems, teachers need to become skilled at using project-based learning focused on student-driven inquiry. In turn, students must learn how to produce ideas, products, and projects that address specific questions. This laminated Quick Reference Guide, based on Dr. William N. Bender’s book 20 Strategies for STEM Instruction, provides at-a-glance instructional strategies to deepen student learning in a STEM setting. This resource addresses engineering, coding, robotics, and augmented reality along with ways to leverage flipped classrooms, rubrics, hypothesis testing, and goal-setting. It also advises on differentiation and helping students self-evaluate.